Publications by authors named "Nico A Schlaudraff"
Int J Cancer
January 2025
Article Synopsis
- SIAH3, a member of the SIAH family in humans, is often silenced in various cancers like melanoma and lung adenocarcinoma, leading to worse survival for patients.
- Inducing SIAH3 expression can decrease cancer cell growth and trigger cell death, as it shifts cellular energy production from aerobic metabolism to glycolysis.
- SIAH3 is found in mitochondria and interacts with proteins related to mitochondrial function and other ubiquitin ligases, suggesting it plays a role as a tumor suppressor by regulating metabolism.
