Publications by authors named "Nico A Janssen"
Article Synopsis
- Invasive pulmonary aspergillosis (IPA) is increasingly seen in critically ill patients with viral pneumonia, particularly those with influenza (IAPA) and COVID-19 (CAPA).
- Both IAPA and CAPA are associated with high mortality rates, affecting mostly previously healthy individuals.
- The article explores the unknown mechanisms behind IAPA and CAPA, potential immunotherapy options, and the challenges that lie ahead in managing these infections.
Background: Knowledge on bacterial co-infections in COVID-19 is crucial to use antibiotics appropriately. Therefore, we aimed to determine the incidence of bacterial co-infections, antibiotic use and application of antimicrobial stewardship principles in hospitalized patients with COVID-19.
Methods: We performed a retrospective observational study in four hospitals (1 university, 2 non-university teaching, 1 non-teaching hospital) in the Netherlands from March to May 2020 including consecutive patients with PCR-confirmed COVID-19.
Article Synopsis
- Immune reconstitution inflammatory syndrome (IRIS) is a condition that happens when someone's immune system starts to recover, but it causes serious inflammation and tissue damage, making them feel worse.
- This usually includes symptoms like fever and might show new infections that weren’t noticed before.
- IRIS often occurs in people with HIV when their treatment helps their immune system, but it's also seen in cancer patients recovering from low white blood cells after treatments like chemotherapy.
Bacteroides fragilis, an intestinal flora commensal microorganism, is frequently isolated from abscesses and soft tissue infections. This study aimed to identify pattern recognition receptors (PRRs) involved in B. fragilis recognition and to characterize the induced cytokine profile.
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