Design, synthesis and antimycobacterial activity of imidazo[1,5-]quinolines and their zinc-complexes.

Tuberculosis has remained one of the world's deadliest infectious diseases. The complexity and numerous adverse effects of current treatment options as well as the emergence of multi-drug resistant (Mtb) demand research and innovation efforts to yield new anti-mycobacterial agents. In this study, we synthesized a series of imidazo[1,5-]quinolines, including 4 new analogs, and evaluated their activity against Mtb.