Sugar substitutes on caries prevention in permanent teeth among children and adolescents: a systematic review and meta-analysis.

Objectives: This study aimed to systematically review the effect of sugar substitute consumption on caries prevention in permanent teeth among children and adolescents.

Data: Randomized controlled trials (RCTs) and controlled clinical trials (CCTs) comparing the clinical effect of sugar substitutes (both high- and low-intensity sweeteners) in preventing caries in permanent teeth among children and adolescents aged 6-19 were included.

Sources: A systematic search was conducted in three databases (PubMed, Web of Science and Embase) without any restrictions on publication year.

Clinical Effects of Sugar Substitutes on Cariogenic Bacteria: A Systematic Review and Meta-Analysis.

Background: The use of sugar substitutes in food products has recently increased. Limited information regarding the role of various sugar substitutes in caries prevention was found. This systematic review and meta-analysis was conducted to investigate the effects of sugar substitute consumption on reducing cariogenic bacteria in dental plaque and saliva.