Publications by authors named "Nickpreet Singh"
Background: Bleeding events after arterial transcatheter procedures are associated with increased morbidity and mortality. The frequency and clinical implications of bleeding after mitral transcatheter edge-to-edge repair (M-TEER) have not been well-studied.
Objectives: The authors sought to explore the association of in-hospital bleeding events after M-TEER with patient outcomes.
Background: Diffuse low-grade gliomas (DLGGs) represent several pathological entities that infiltrate and invade cortical and subcortical structures in the brain.
Objective: To describe methods for rapid prototyping of DLGGs and surgically relevant anatomy.
Methods: Using high-definition imaging data and rapid prototyping technologies, we were able to generate 3 patient DLGGs to scale and represent the associated white matter tracts in 3 dimensions using advanced diffusion tensor imaging techniques.
Article Synopsis
- The article explores the integration of 3D printing in neurosurgery, reviewing its potential benefits and applications across various subspecialties.* -
- A systematic search of multiple medical databases identified 36 relevant articles that highlight the diverse uses of 3D printing, including surgical planning and training.* -
- The findings suggest that 3D printing offers practical, patient-specific models that could enhance surgical techniques and patient outcomes in neurosurgery.*
Article Synopsis
- - Cervical teratomas are uncommon tumors in fetuses that can lead to serious complications like airway obstruction during delivery and can cause polyhydramnios due to the fetus's inability to properly swallow amniotic fluid.
- - Advances in prenatal diagnosis using imaging techniques have greatly improved how these cases are managed before and during birth.
- - In the case reported, a fetus was diagnosed with a large cervical teratoma while being monitored for polyhydramnios, and surgery was performed to remove the tumor after ensuring the airway was secure, demonstrating effective treatment strategies.
Background: Arteriovenous malformations (AVMs) represent a complex pathologic entity in terms of their associated angioarchitecture and blood flow dynamics.
Methods: Using existing imaging data, we generated a patient's giant AVM to scale.
Results: A series of 3-dimensional (3D) models were generated and blood flow dynamics were represented.
Background: Advances in white matter tractography enhance neurosurgical planning and glioma resection, but white matter tractography is limited by biological variables such as edema, mass effect, and tract infiltration or selection biases related to regions of interest or fractional anisotropy values.
Objective: To provide an automated tract identification paradigm that corrects for artifacts created by tumor edema and infiltration and provides a consistent, accurate method of fiber bundle identification.
Methods: An automated tract identification paradigm was developed and evaluated for glioma surgery.
Restriction of nutrients and oxygen in the tumor microenvironment disrupts ER homeostasis and adaptation to such stress is mediated by the key UPR effector PERK. Given its pro-tumorigenic activity, significant efforts have been made to elucidate the molecular mechanisms that underlie PERK function. Chemical-genetic approaches have recently proven instrumental in pathway mapping and interrogating kinase function.
View Article and Find Full Text PDFThe endoplasmic reticulum (ER) resident PKR-like kinase (PERK) is necessary for Akt activation in response to ER stress. We demonstrate that PERK harbors intrinsic lipid kinase, favoring diacylglycerol (DAG) as a substrate and generating phosphatidic acid (PA). This activity of PERK correlates with activation of mTOR and phosphorylation of Akt on Ser473.
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