Determining Collisional Cross Sections from Ion Decay with Individual Ion Mass Spectrometry.

Collision cross section (CCS) measurements determined by ion mobility spectrometry (IMS) provide useful information about gas-phase protein structure that is complementary to mass analysis. Methods for determining CCS without a dedicated IMS system have been developed for Fourier transform mass spectrometry (FT-MS) platforms by measuring the signal decay during detection. Individual ion mass spectrometry (IMS) provides charge detection and measures ion lifetimes across the length of an FT-MS detection event.