Publications by authors named "Nick Savill"
Article Synopsis
- The transition of mammalian parasites from "slender" to "stumpy" forms occurs through a process regulated by quorum-sensing, marking a key morphological change during infection.
- Research shows that once parasites enter the "stumpy" phase, they undergo an irreversible developmental arrest, impacting their ability to replicate in both acute and chronic infections in mice.
- Analysis reveals that while stumpy forms dominate, replicating parasites are rare in the bloodstream once the infection is established, suggesting these parasites have adapted more for transmission rather than proliferation or evading the immune system.
On average, more than two new species of human virus are reported every year. We constructed the cumulative species discovery curve for human viruses going back to 1901. We fitted a statistical model to these data; the shape of the curve strongly suggests that the process of virus discovery is far from complete.
View Article and Find Full Text PDFLivestock movement is thought to be a risk factor for the transmission of infectious diseases of farm animals. Simple mathematical models were constructed for the transmission of Escherichia coli serogroup O157 between Scottish cattle farms, and the models were used in a preliminary exploration of factors contributing to the levels of infection reported in the field. The results suggest that cattle movement can make a significant contribution to the observed prevalence of E.
View Article and Find Full Text PDF