Publications by Nick R Burwick

Publications by authors named "Nick R Burwick"

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An Inhibitor of the F1 subunit of ATP synthase (IF1) modulates the activity of angiostatin on the endothelial cell surface.

Nick R Burwick Miriam L Wahl Jun Fang Zhaoxi Zhong Tammy L Moser

J Biol Chem

January 2005

Angiostatin binds to endothelial cell (EC) surface F(1)-F(0) ATP synthase, leading to inhibition of EC migration and proliferation during tumor angiogenesis. This has led to a search for angiostatin mimetics specific for this enzyme. A naturally occurring protein that binds to the F1 subunit of ATP synthase and blocks ATP hydrolysis in mitochondria is inhibitor of F1 (IF1).

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