Publications by authors named "Nick Olney"
Article Synopsis
- ALS is a fast-progressing neurodegenerative disease with no cure and limited treatment options, creating a need for better therapies.
- A study was conducted to examine the effects of memantine on ALS progression and related cognitive and behavioral changes using a randomized, placebo-controlled trial with 89 participants.
- Results showed that memantine did not significantly affect the progression of ALS, biomarker changes, or neuropsychiatric symptoms compared to a placebo.
Frontotemporal dementia refers to a group of progressive neurodegenerative syndromes usually caused by the accumulation of pathological tau or TDP-43 proteins. The effects of these proteins in the brain are complex, and each can present with several different clinical syndromes. Clinical efficacy trials of drugs targeting these proteins must use endpoints that are meaningful to all participants despite the variability in symptoms across patients.
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