Epidemiological study of alendronate-related osteonecrosis of the jaw in the southeast of Scotland.

We aimed to establish the incidence of alendronate-related osteonecrosis of the jaw (ONJ) in the southeast of Scotland, and to assess the effect of corticosteroids on it. We studied a prospective case series of patients between June 2004 and March 2012 separated into steroid and non-steroid groups. There were 34 cases of alendronate-related ONJ and 78732 drug patient years (DPY) of alendronate, making the overall occurrence 43.

Summary of: a study of 225 patients on bisphosphonates presenting to the bisphosphonate clinic at King's College Hospital.

Aim: The aim of this retrospective study was to examine the outcome of patients referred to a dedicated clinic for dental extractions while they were prescribed either oral or intra-venous (IV) bisphosphonates (BPs). The following parameters were assessed: mode of BP administration, indication for BP prescription, incidence of BRONJ, concomitant risk factors for development of bisphosphonate-related osteonecrosis of the jaws (BRONJ) and demographic details.

Material And Methods: The clinical records of 225 patients who underwent dental extraction while receiving oral or intravenous bisphosphonates were reviewed.

An epidemiological study of alendronate-related osteonecrosis of the jaws. A case series from the south-east of Scotland with attention given to case definition and prevalence.

A close case study series of alendronate-associated osteonecrosis of the jaws (AONJ) is presented. A consistency of case definition with a minimal reporting requirement was attempted as recommended by the task force of the American Society for Bone and Mineral Research. A hierarchy of evidence focussing on 7 categories of interest was included for each case.

Coronectomy of a third molar with cyst lining enucleation in the management of a dentigerous cyst.

Unlabelled: A dentigerous cyst was treated with enucleation and coronectomy of the associated tooth to minimize the risk of inferior alveolar nerve damage, resulting from direct surgical trauma or indirectly from intra-operative or post-operative jaw fracture. Radiographic monitoring over 33 months confirmed migration of the roots through healed bone and progressive obliteration of the residual pulp canal chamber. These observations are not associated with failure of the technique but are, in fact, commonly observed in successful cases of coronectomy.

Lingual mucosal ulceration with mandibular sequestration.

Unlabelled: Lingual mucosal ulceration with mandibular sequestration is a condition that presents most commonly in the lower molar region and may be influenced by a variety of local and systemic factors. Three such cases are reported, two involving a history of recent dental extraction and one of seemingly spontaneous onset with the possibility of an underlying association with bisphosphonate therapy. An overview of the surgical and non-surgical management strategies for such cases is described.

Dental procedures can be undertaken without alteration of oral anticoagulant regimen.

Data Sources: Medline provided the primary data source with references from identified articles being reviewed for additional studies. The Cochrane Collaboration database was also searched and a search performed of cited references.

Study Selection: Clinical studies, in English, examining perioperative management of patients receiving long-term oral anticoagulant (OAC) therapy were selected.