Publications by authors named "Nick J Brooks"
Article Synopsis
- Hemostatic defects require coagulation factors and a phospholipid surface for clot formation, and the study identifies that oxidized phospholipids (HETE-PLs) from immune cells can restore the ability to stop bleeding in both human and mouse models of bleeding disorders.
- HETE-PLs significantly reduced blood loss in mouse hemophilia A and improved blood coagulation in human plasma with various factor deficiencies, indicating their potential therapeutic role in treating bleeding conditions.
- The research demonstrated that HETE-PLs enhance the activity of critical coagulation complexes and may improve factor binding and accessibility, suggesting they could be useful in managing bleeding disorders effectively.
