Publications by authors named "Nick Graziane"
Article Synopsis
- Synaptic spines are key structures that influence how neurons respond and adapt, and the research focuses on how the schizophrenia risk factor DISC1 affects these spines’ shape and function.*
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- The study discovered that DISC1 helps control the activity of the protein Kalirin-7, which in turn governs Rac1 activation linked to NMDA receptor activity, impacting spine size and function.*
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- Findings suggest a connection between glutamatergic transmission issues in schizophrenia and changes in dendritic spines, highlighting the potential role of a complex network involving DISC1 and glutamate in the disorder.*
