Publications by authors named "Nick D James"
Article Synopsis
- BC2001 study investigated the impact of combining chemotherapy with radiotherapy to improve survival rates in patients with muscle-invasive bladder cancer (MIBC), focusing on a 24-gene hypoxia-associated signature to identify potential treatment benefits.
- Analysis revealed that the level of hypoxia in tumors did not significantly influence the effectiveness of chemotherapy in BC2001, and both high and low hypoxia scores experienced similar outcomes.
- The study found that while high hypoxia scores correlated with worse invasive loco-regional control with hypofractionated radiotherapy, this effect was not observed in patients receiving conventional radiotherapy.
Objectives: To compare the MRI texture profile of acetabular subchondral bone in normal, asymptomatic cam positive, and symptomatic cam-FAI hips and determine the accuracy of a machine learning model for discriminating between the three hip classes.
Methods: A case-control, retrospective study was performed including 68 subjects (19 normal, 26 asymptomatic cam, 23 symptomatic cam-FAI). Acetabular subchondral bone of unilateral hip was contoured on 1.
Objectives: The purpose of this study was to determine if the CT texture profile of acetabular subchondral bone differs between normal, asymptomatic cam-positive, and symptomatic cam-FAI hips. In addition, the utility of texture analysis to discriminate between the three hip statuses was explored using a machine learning approach.
Methods: IRB-approved, case-control study analyzing CT images in subjects with and without cam morphology from August 2010 to December 2013.