Nystagmus and reduced visual acuity secondary to drug exposure in utero: long-term follow-up.

Purpose: To investigate nystagmus and other visual system abnormalities among children exposed to opiates and benzodiazepines in utero.

Methods: Retrospective case series comprising clinical examination and case note review of 25 children with nystagmus and reduced vision who were exposed to controlled drugs during pregnancy.

Results: Twenty-four children were exposed to opiates, of whom 13 were also exposed to diazepam.

Replication of the recessive STBMS1 locus but with dominant inheritance.

Purpose: Strabismus is a common eye disorder with a prevalence of 1% to 4%. Comitant strabismus accounts for approximately 75% of all strabismus, yet more is known about the less common incomitant disorders. Comitant strabismus is at least partly inherited, but only one recessive genetic susceptibility locus, on chromosome 7p, has been identified in one family.

Nystagmus secondary to drug exposure in utero.

Aim: To report the occurrence of nystagmus in children exposed to opiates and/or benzodiazepines during pregnancy, and to describe the associated ocular and systemic findings.

Methods: Clinical examination and casenote review of 14 children with nystagmus whose mothers had misused opiates and/or benzodiazepines during pregnancy.

Results: Twelve children were exposed to opiates during pregnancy, of whom nine had also been exposed to benzodiazepines.

Infective endocarditis presenting with Parinaud's dorsal midbrain syndrome.

We present a case of vertical gaze palsy in a 13-year-old girl caused by underlying infective endocarditis, secondary to an infected navel piercing. This case illustrates that infective endocarditis does not always present with classic signs.

Tied and tidy: closing the conjunctiva over adjustable sutures.

Background: Adjustable sutures have revolutionized strabismus surgery. Numerous techniques have been described that aim to facilitate postoperative adjustment. Nevertheless, some sort of procedure is always necessary following adjustable suture surgery and has to be arranged within 24 hours.