Development of a validation imaging dataset for Molecular Radiotherapy dosimetry multicenter intercomparison exercises based on anthropomorphic phantoms.

Unlabelled: Validation of a Molecular Radiotherapy (MRT) dosimetry system requires imaging data for which an accompanying "ground truth" pharmacokinetic model and absorbed dose calculation are known.

Methods: We present a methodology for production of a validation dataset for image based Lu dotatate dosimetry calculations. A pharmacokinetic model is presented with activity concentrations corresponding to common imaging timepoints.

Positional dependence of activity determination in single photon emission computed tomography.

Accurate image quantification requires accurate calibration of the detector and is vital if dosimetry is to be performed in molecular radiotherapy. A dependence on the position of calibration has been observed in single photon emission computed tomography images when attenuation correction (AC) and scatter correction are applied. This work investigates the origin of this dependence in single photon emission computed tomography scans of phantom inserts filled with Lu solution.

Improving molecular radiotherapy dosimetry using anthropomorphic calibration.

Unlabelled: The optimised delivery of Molecular Radiotherapy requires individualised calculation of absorbed dose to both targeted lesions and neighbouring healthy tissue. To achieve this, accurate quantification of the activity distribution in the patient by external detection is vital.

Methods: This work extends specific anatomy-related calibration to true organ shapes.

Enhanced recovery principles applied to revision hip and knee arthroplasty reduces length of stay and blood transfusion.

Introduction: This is the first study reporting the application of Enhanced Recovery Principles (ERP) to revision arthroplasty.

Method: Retrospective series of 132 revision hip and knee replacements treated with ERP.

Results: Infiltration was associated with reduced LOS in knees (6 vs 8.

The outcomes of pregnancies following a prenatal diagnosis of fetal exomphalos in Western Australia.

Aims: To review the perinatal outcomes for prenatally diagnosed exomphalos from a single geographical region.

Methods: Retrospective review of cases of prenatally identified exomphalos in the state of Western Australia in the ten-year period 1998-2007 using the medical databases of the sole tertiary obstetric and paediatric hospitals.

Results: Ninety-four cases of prenatally identified exomphalos comprise this consecutive case series.