Publications by authors named "Nick Ballew"
Clin Kidney J
January 2024
Article Synopsis
- Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are new oral treatments for anemia in chronic kidney disease (CKD) that were compared in a study of dialysis and non-dialysis patients using network meta-analyses.*
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- The study looked at three main outcomes: changes in hemoglobin levels, the risk of major cardiovascular events, and quality of life through a health survey, analyzing data from seventeen phase III trials involving nearly 8,000 patients.*
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- The results indicated no significant differences in hemoglobin changes or cardiovascular risk among the three HIF-PHIs, but daprodustat showed a greater improvement in quality of life compared to roxad
Article Synopsis
- The study aims to compare the effectiveness of belimumab versus anifrolumab in treating systemic lupus erythematosus (SLE) to guide treatment decisions.
- By analyzing data from eight randomized trials using a method called multilevel network meta-regression, researchers assessed the SLE Responder Index (SRI)-4 response after 52 weeks of treatment.
- Results indicate that both medications show similar effectiveness, with belimumab appearing slightly more effective, but the uncertainty in results leaves open the possibility of either treatment being more beneficial for specific patient groups.
