Publications by authors named "Nicholas Yap"

Mitogenomics has improved our understanding of medusozoan phylogeny. However, sequenced medusozoan mitogenomes remain scarce, and Medusozoa phylogeny studies often analyze mitogenomic sequences without incorporating mitogenome rearrangements. To better understand medusozoan evolution, we analyzed Medusozoa mitogenome phylogeny by sequencing and assembling eight mitogenomes from three classes (Cubozoa, Hydrozoa, and Scyphozoa).

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Sea anemones (Cnidaria, Actiniaria) are a successful group of marine invertebrates found in a diverse range of environments globally. In spite of their ubiquity, identities for many sea anemones remain unverified, especially those from the Indo-West Pacific region. Here, we clarify the taxonomy of the poorly known , a shallow-water species first described from the Torres Straits in northern Australia.

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Haloclavidae Verrill, 1899 is a family of burrowing sea anemones grouped within the superfamily Actinioidea (Rafinesque, 1815). Currently, it includes 30 species in 10 genera. Characters given for this family in descriptions of its taxa have not been consistent, with numerous exceptions to the expectations of the familial diagnosis.

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Article Synopsis
  • The intertidal polychaete Spirobranchus kraussii was originally described in South Africa, but recent studies revealed it consists of multiple similar species, prompting a need for taxonomic revisions.
  • Researchers have identified a new species, Spirobranchus bakau sp. nov., from Singapore's mangroves using morphological and molecular techniques, confirming its genetic distinction from S. kraussii and related species.
  • The study also examined fertilization and embryonic development of S. bakau sp. nov. under varying salinities and temperatures, finding high fertilization success but narrower salinity tolerance for embryonic development, aiding future research on the species' distribution.
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Despite the ubiquity of sea anemones (Cnidaria: Actiniaria) in tropical ecosystems, our understanding of their biodiversity and taxonomy is limited. Here we re-establish the identity of an intertidal zooxanthellate species, Martens in Klunzinger, 1877. Originally described from a single preserved specimen in the Berlin Museum by CB Klunzinger, his brief footnote lacked crucial details to positively identify the species.

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Macrophage Receptor with COllagenous structure (MARCO) is a class A scavenger receptor that binds, phagocytoses, and modifies inflammatory responses to bacterial pathogens. Multiple candidate gene approach studies have shown that polymorphisms in MARCO are associated with susceptibility or resistance to Mycobacterium tuberculosis infection, but how these variants alter function is not known. To complement candidate gene approach studies, we previously used phylogenetic analyses to identify a residue, glutamine 452 (Q452), within the ligand-binding Scavenger Receptor Cysteine Rich domain as undergoing positive selection in humans.

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The class A scavenger receptor (cA-SR) family is a group of five evolutionarily related innate immune receptors. The cA-SRs are known for their promiscuous ligand binding; as they have been shown to bind bacteria, such as Streptococcus pneumoniae and Escherichia coli, as well as different modified forms of low-density lipoprotein. Three of the five family members possess a scavenger receptor cysteine-rich (SRCR) domain while the remaining two receptors lack the domain.

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Nanocrystalline molybdenum oxide (α-MoO3) thin films with iso-oriented crystalline layers were synthesised by the anodisation of Mo foils. Upon band-gap excitation using light illumination, α-MoO3 generates excited electrons for reductive reactions and stores some of the excited electrons in its layered crystalline structure via alkali cation intercalation. These stored electrons can be subsequently discharged from α-MoO3 to allow reductive reactions to continue to occur under non-illuminated conditions.

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Bioinformatics includes a suite of methods, which are cheap, approachable, and many of which are easily accessible without any sort of specialized bioinformatic training. Yet, despite this, bioinformatic tools are under-utilized by immunologists. Herein, we review a representative set of publicly available, easy-to-use bioinformatic tools using our own research on an under-annotated human gene, SCARA3, as an example.

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