Publications by authors named "Nicholas W Barnes"
Article Synopsis
- The selectivity of drugs for their target receptors is vital for effective treatment, but distinguishing between similar receptors poses a challenge.
- The discovery of ligands that preferentially activate target receptors over closely related ones, despite similar binding affinities, points to a phenomenon called 'efficacy-driven selectivity.'
- Using atomic-level simulations, researchers identified how the drug xanomeline interacts differently with inactive and active states of muscarinic acetylcholine receptors, paving the way for designing drugs with enhanced selectivity for important receptors.
