Publications by authors named "Nicholas Vannuchi"

Article Synopsis
  • Obesity and its related inflammation are major health issues, and anthocyanins—compounds found in fruits and veggies—show promise in helping to combat these problems.
  • The review examines how the effects of anthocyanins on obesity can vary with different dosages, looking at their absorption, structure, and how they interact with the gut microbiota and immune responses.
  • It emphasizes the need for more research to determine the optimal dosages for anthocyanins to maximize health benefits, considering individual differences and potential clinical applications for obesity management.
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Anthocyanins extracted with deep eutectic solvent (NADES) (chlorine-chloride: xylitol, 5:2) were used to produce polyethylene oxide (PEO) composites through electrospinning technique, analyzing their microscopic and physical characteristics. The coated anthocyanins were then subjected to in vitro gastrointestinal digestion to evaluate their bioaccessibility compared to lyophilized jussara pulp. The remaining total anthocyanin content (TAC) after intestinal in vitro digestion did not change significantly among the assessed samples, and both showed around 30% recovery.

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In this article, we reviewed studies on the fruits of the jussara palm (Euterpe edulis Martius), an endangered Brazilian Atlantic Forest palm tree, also coined as "Superfruit." We summarized the chemical components of the pulp and observed biological activities in murine and humans, as well as the best practices involving the extraction of its target compounds, bioavailability, and stability of extracts. Jussara has shown a rich phenolic profile that justifies its antioxidant properties, in addition to a considerable lipidic and energetic value.

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Thirteen pyrrolidine-based iminosugar derivatives have been synthesized and evaluated for inhibition of α-glucosidase from rat intestine. The compounds studied were the non-hydroxy, mono-hydroxy and dihydroxypyrrolidines. All the compounds were N-benzylated apart from one.

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