Publications by authors named "Nicholas Tomlinson"

Article Synopsis
  • - Metastatic colorectal cancer (mCRC) significantly contributes to cancer-related deaths with current treatments only relieving symptoms and resulting in a low survival rate of around 11%.
  • - T-cell factor (TCF) transcription plays a crucial role in mCRC by driving a process called epithelial-mesenchymal transition (EMT), leading to drug resistance and cancer spread.
  • - Researchers have developed TOP2A ATP-competitive inhibitors that target TCF-transcription without causing DNA damage, representing a promising new treatment strategy for mCRC and potentially other cancers.
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This study was designed to investigate the antimicrobial effects of CDots in combination with other antimicrobial reagents, including H2O2, Na2CO3, and AcOH (acetic acid). CDots were synthesized and passivated with 2,2'-(ethylenedioxy)bis(ethylamine) (EDA). The minimal inhibitory concentration (MIC) of CDots was 64 μg/mL on both Gram negative bacteria E.

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Carbon dots are small carbon nanoparticles with various surface passivation schemes, in which more effective has been the deliberate chemical functionalization of the nanoparticles for brighter fluorescence emissions, though the synthesis method is more tedious and subject to some limitations in the selection of functionalization molecules. Another more popular synthesis method has been the carbonization of organic species, with the method being more efficient and versatile, but less controllable in the synthesis and for the desired dot structure and performance. In this work, a hybrid approach combining the advantageous characteristics of the two synthesis methods was applied to the preparation of carbon dots with polyethyleneimine (PEI) for surface passivation, where pre-processed and selected small carbon nanoparticles were functionalized with PEI in microwave-induced thermal reactions.

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