Publications by authors named "Nicholas Toalster"
Article Synopsis
- Over the past 40 years, around 40,000 Australians have undergone corneal transplants, primarily due to conditions like keratoconus and Fuchs' dystrophy, with increasing demand due to an aging population.
- The global shortage of donor corneas is significant, with demand exceeding supply by 70 times, particularly in less-developed countries, prompting advancements in tissue banking and surgical techniques.
- New strategies like organ culture for donor corneas, bespoke surgical methods, and cell culture technologies are improving tissue storage, reducing transplant requirements, and enhancing patient care for corneal conditions.
Introduction: This study examined the distribution of histopathological disease severity amongst a cohort of patients treated for clinically suspected ocular surface squamous neoplasia and evaluated the relationship between various patient and clinical factors and the severity of pathological grade as well as treatment outcomes.
Methods: A retrospective cohort study of demographic and clinicopathological factors of 150 patients clinically diagnosed with suspected ocular surface squamous neoplasia who underwent excision of lesion with histopathological diagnosis.
Results: The study included 125 cases; the mean age at diagnosis was 64 years (SD = 11.
Purpose: To report early safety and efficacy of Descemet stripping only (DSO) supplemented with ripasudil.
Methods: A pre-post clinical trial with a historical control group for time to heal and cell count parameters. The study received ethics approval and was conducted with oversight of a data safety monitoring board.
Purpose: To describe a novel pedicled temporo-parietal flap to delay laminar resorption in a modified osteo-odonto keratoprosthesis (MOOKP) and measure resorption of the dental lamina by an objective method.
Methods: A retrospective case series was performed on patients who received an osteo-odontokeratoprosthesis for Steven-Johnson-Syndrome. Surgeries were performed between October 2016 and November 2017 by the same surgical team (G.
Purpose Of Review: To summarize the recent literature regarding descemetorhexis stripping without endothelial keratoplasty (DWEK), increasingly referred to as Descemet's stripping only (DSO). To report the characteristic clinical, confocal and histologic findings associated with this procedure.
Recent Findings: Reported clearance rates following DSO range from 63 to 100% in recent series, with variation between surgical techniques.
Periorbital and conjunctival oedema has been reported anecdotally by patients with raised intracranial pressure states. We present three clinical cases of this phenomenon and discuss the current evidence for pathways by which cerebrospinal fluid (CSF) drains in relation to conjunctival oedema. We reviewed the available literature using PubMed, in regards to conjunctival oedema as it relates to intracranial hypertension, and present the clinical history, radiology and orbital photographs of three cases we have observed.
View Article and Find Full Text PDFPurpose: To evaluate the safety and efficacy of a strictly applied inject and extend protocol for ranibizumab treatment of age-related macular degeneration.
Methods: This is a prospective, multicenter, nonrandomized trial. Patients underwent standard induction with 3 intravitreal doses of 0.