Publications by authors named "Nicholas Tjahjono"
The bacterial extracellular matrix forms autonomously, giving rise to complex material properties and multicellular behaviors. Synthetic matrix analogues can replicate these functions but require exogenously added material or have limited programmability. Here, we design a two-strain bacterial system that self-synthesizes and structures a synthetic extracellular matrix of proteins.
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- The ESCRT complexes are crucial for processes like HIV-1 release, autophagosome closure, and cell division, with ESCRT-I being the primary complex that connects to HIV-1 Gag during virus release.
- Researchers determined the crystal structure of the human ESCRT-I headpiece, revealing it consists of a helical assembly with a repeating pattern of 12 molecules, which was confirmed through electron microscopy.
- Mutations in specific regions of the VPS28 protein prevent the formation of the ESCRT-I filaments, which impairs key cellular processes like HIV-1 release and autophagosome closure, highlighting the complex's important structural and functional roles.