Endometrial receptivity defects during IVF cycles with and without letrozole.

Background: Our aim was to study ways to improve IVF success rates in women with suspected endometrial receptivity defects.

Methods: We conducted a retrospective cohort study examining the effect of letrozole (aromatase inhibitor) on integrin expression as a marker of endometrial receptivity. We compared IVF outcomes in 97 infertile women who had undergone ανβ3 integrin assessment by immunohistochemistry in mid-luteal endometrial biopsies.