Publications by authors named "Nicholas Sathi"
Article Synopsis
- Rapid eye movement sleep (REMs) is vital for vivid dreaming and is regulated by the body, compensating for any losses in REMs sleep.
- Researchers found that specific GABAergic neurons in the preoptic area of the hypothalamus are essential for managing REMs in mice, becoming more active during REMs periods.
- When these neurons are inhibited, REMs sleep decreases, and disrupting their function during REMs deprivation prevents the body from rebounding the necessary REMs sleep afterward.
Rapid-eye-movement sleep (REMs) is characterized by activated electroencephalogram (EEG) and muscle atonia, accompanied by vivid dreams. REMs is homeostatically regulated, ensuring that any loss of REMs is compensated by a subsequent increase in its amount. However, the neural mechanisms underlying the homeostatic control of REMs are largely unknown.
View Article and Find Full Text PDFSleep disturbances in autism spectrum disorder: Animal models, neural mechanisms, and therapeutics.
Neurobiol Sleep Circadian Rhythms
May 2023
Sleep is crucial for brain development. Sleep disturbances are prevalent in children with autism spectrum disorder (ASD). Strikingly, these sleep problems are positively correlated with the severity of ASD core symptoms such as deficits in social skills and stereotypic behavior, indicating that sleep problems and the behavioral characteristics of ASD may be related.
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