Publications by authors named "Nicholas Pudjihartono"
The ubiquitin-conjugating E2 enzymes play a central role in ubiquitin transfer. Disruptions to the ubiquitin system are implicated in multiple diseases, and as a result, molecules that modulate the activity of the ubiquitin system are of interest. E2 enzyme function relies on interactions with partner proteins, and the disruption of these is an effective way to modulate activity.
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- Researchers are focusing on identifying genetic drivers in melanoma, especially in unexplored non-coding regions, to develop targeted treatments.
- Using Hi-C chromatin contact data, they mapped regulatory elements that interact with promoters and identified mutation hotspots affecting gene expression.
- The study reveals eight new melanoma-specific mutation hotspots that alter gene expression related to cancer, highlighting the importance of non-coding mutations in melanoma development and offering a new framework for cancer research.
Machine learning has shown utility in detecting patterns within large, unstructured, and complex datasets. One of the promising applications of machine learning is in precision medicine, where disease risk is predicted using patient genetic data. However, creating an accurate prediction model based on genotype data remains challenging due to the so-called "curse of dimensionality" (i.
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