Publications by authors named "Nicholas Murner"
Article Synopsis
- The study focuses on a critical infection-causing pathogen, examining a specific carbohydrate structure (GAC) essential for its disease-causing abilities and diagnostic recognition.*
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- Researchers discovered genetic variations in the GAC biosynthesis genes among various strains, especially noting a premature stop codon that leads to the loss of a crucial side chain, affecting the bacterium's immune response.*
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- The findings provide insights into how genetic variations influence the bacterium's ability to evade the human immune system and highlight the significance of GacH in maintaining the pathogen's structural integrity.*
Article Synopsis
- The study focuses on the specific carbohydrate (SCC) produced by the bacteria that cause dental caries, which is essential for their survival.
- SCC features a structure made of a polyrhamnose backbone with glucose side-chains and glycerol phosphate decorations, and the research identifies one major and two minor glucose modifications on this carbohydrate.
- The major glucose modification is crucial for biofilm formation and is created by specific enzymes, while both major and minor modifications affect the shape of the bacteria.
