Susceptibility of to Tigecycline in a Cell Culture Assay and Animal Model for Rocky Mountain Spotted Fever.

Rocky Mountain spotted fever (RMSF), caused by , is a severe tick-borne infection endemic to the Americas. Oral doxycycline is effective, but during severe life-threatening disease, intravenous therapy is recommended. Unfortunately, intravenous formulations of doxycycline are not always available.

Statin Use and 25-Hydroxyvitamin D Blood Level Response to Vitamin D Treatment of Older Adults.

Objectives: To determine whether statin use alters response of 25-hydroxyvitamin D (25(OH)D) level to vitamin D treatment.

Design: Pooled analysis.

Setting: Three double-blind randomized controlled trials that tested different doses of vitamin D.

Associations between drug burden index and mortality in older people in residential aged care facilities.

Background: The Drug Burden Index (DBI), a measure of an individual's exposure to anticholinergic and sedative medications, is associated with functional impairment in community-dwelling, older people. In people from residential aged care facilities (RACFs), DBI score does not appear to be associated with functional impairment, but is associated with an increased risk of falls.

Objective: We investigated the associations between increasing DBI score and mortality in older adults living in RACFs.

Associations between drug burden index and falls in older people in residential aged care.

Objectives: To evaluate the association between the Drug Burden Index (DBI), a measure of a person's total exposure to anticholinergic and sedative medications that includes principles of dose-response and maximal effect and is associated with impaired physical function in community-dwelling older people, and falls in residents of residential aged care facilities (RACFs).

Design: Data were drawn from participants in a randomized controlled trial that investigated falls and fractures.

Setting: RACFs in Sydney, Australia.

Medication safety in residential aged-care facilities: a perspective.

Medication safety must be tailored to the distinctive issues in residential aged-care facilities (RACFs). The health and functional characteristics of their residents are different to those of hospital inpatients and community-dwelling older adults, and there are unique staffing and management issues. Understanding the aetiology and epidemiology of drug-related problems is vital in developing methods to improve patient safety.