Pharmacokinetics and pharmacodynamics of repeat dosing of gabapentin in adult horses.

Background: The repeated administration of high doses of gabapentin may provide better analgesia in horses than current clinical protocols.

Hypothesis And Objectives: Administration of gabapentin at 40 and 120 mg/kg PO q 12 h for 14 days will not alter serum biochemistry findings or cause adverse effects. Our objectives were to evaluate the effect of gabapentin on serum biochemistry, physical examination, and plasma pharmacokinetics of gabapentin.