Tissue-specific dynamic codon redefinition in .

Translational stop codon readthrough occurs in organisms ranging from viruses to mammals and is especially prevalent in decoding and viral mRNAs. Recoding of UGA, UAG, or UAA to specify an amino acid allows a proportion of the protein encoded by a single gene to be C-terminally extended. The extended product from mRNA is 160 kDa, whereas unextended Kelch protein, a subunit of a Cullin3-RING ubiquitin ligase, is 76 kDa.