Parallel evolution of linezolid-resistant in patients with cystic fibrosis.

Linezolid is an antibiotic used to treat serious infections. Resistance to linezolid is considered rare but could emerge with repeated dosing. We recently reported widespread prescription of linezolid for a cohort of patients with cystic fibrosis (CF).

Parallel Evolution of Linezolid Resistant in Patients with Cystic Fibrosis.

Background: Linezolid is an antibiotic used to treat serious infections. Resistance to linezolid is considered rare but could emerge with repeated dosing. We recently reported widespread prescription of linezolid for a cohort of patients with cystic fibrosis (CF).

MRSA strains with distinct accessory genes predominate at different ages in cystic fibrosis.

Rationale: Methicillin resistant Staphylococcus aureus (MRSA) is prevalent and consequential in cystic fibrosis (CF). Whole genome sequencing (WGS) could reveal genomic differences in MRSA associated with poorer outcomes or detect MRSA transmission.

Objectives: To identify MRSA genes associated with low lung function and potential MRSA transmission in CF.