Publications by authors named "Nicholas J Orr"
Nucleic Acids Res
June 2014
Article Synopsis
- In response to genotoxic stress, the TP53 tumor suppressor activates genes that can either halt the cell cycle or trigger apoptosis, while TP63 can repress these effects to promote cell proliferation, especially in squamous cell carcinomas where TP63 is often overexpressed.
- Using ChIP-sequencing and microarray analysis, the researchers studied how TP53 and TP63 interact at the genome level during genotoxic stress in normal cells, finding that they bind to overlapping but different regions of the genome.
- The study showed that different chemotherapeutic agents like cisplatin and adriamycin affect TP53 and TP63 binding in distinct ways, influencing the regulation of numerous genes related to cell cycle control, DNA repair, and apoptosis,
