Publications by authors named "Nicholas J Homa"
Article Synopsis
- Xis is a special protein that helps bend DNA and decides how DNA gets mixed up during a process called recombination.* -
- There are likely four spots on the DNA where Xis can attach, but scientists found that the Xis crystals have five parts that work together to create a bent shape.* -
- In a virus called Pukovnik, Xis and another protein called Int can work together to help form structures that include parts of the DNA needed for this process.*
Oncogenic viruses promote cell proliferation through the dramatic reorganization of host transcriptomes. In addition to regulating mRNA abundance, changes in mRNA isoform usage can have a profound impact on the protein output of the transcriptome. Using Epstein-Barr virus (EBV) transformation of primary B cells, we have studied the ability of an oncogenic virus to alter the mRNA isoform profile of its host.
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