Publications by authors named "Nicholas J Hobson"
Article Synopsis
- Superparamagnetic iron oxide nanoparticles (SPIONs) are used as MRI contrast agents, but many have been withdrawn due to poor performance.
- The study aimed to enhance the T2-weighted MRI contrast of SPIONs by clustering them within a chitosan amphiphile.
- This clustering significantly improved the relaxation ratio, leading to better contrast in MRI images, particularly highlighting liver vasculature when administered intravenously.
Objectives: Dispersible tablets are proposed by the World Health Organization as the preferred paediatric formulation. It was hypothesised that tablets made from a powdered milk-base that disperse in water to form suspensions resembling milk might be a useful platform to improve acceptability in children.
Methods: Milk-based dispersible tablets containing various types of powdered milk and infant formulae were formulated.