Publications by authors named "Nicholas J Fleming"
Objective: The Ossabaw pig is emerging as an attractive model of human cardiometabolic disease because of its size and susceptibility to atherosclerosis, among other characteristics. The relationship between adipose tissue inflammation and metabolic dysfunction in this model was investigated here.
Methods: Young female Ossabaw pigs were fed a Western-style high-fat diet (HFD) (n = 4) or control low-fat diet (LFD) (n = 4) for a period of 9 months and compared for cardiometabolic outcomes and adipose tissue inflammation.
Retention of sedentary obese visceral white adipose tissue phenotype with intermittent physical activity despite reduced adiposity.
Am J Physiol Regul Integr Comp Physiol
September 2015
Article Synopsis
- Regular physical activity significantly reduces inflammation and oxidative stress in visceral white adipose tissue (AT), while intermittent activity also reduces fat mass but does not improve inflammatory markers or metabolic health.
- In a study involving mice, regular activity led to better overall health outcomes compared to intermittent activity, which was linked to a similar reduction in fat but higher inflammation levels.
- Findings suggest that consistent exercise may be more effective than intermittent exercise for reducing inflammation and improving glucose tolerance related to obesity.
We tested the hypothesis that a decrease in bioavailability of nitric oxide (NO) would result in increased adipose tissue (AT) inflammation. In particular, we utilized the obese Otsuka Long Evans Tokushima Fatty rat model (n = 20) and lean Long Evans Tokushima Otsuka counterparts (n = 20) to determine the extent to which chronic inhibition of NO synthase (NOS) with N (ω) -nitro-l-arginine methyl ester (L-NAME) treatment (for 4 weeks) upregulates expression of inflammatory genes and markers of immune cell infiltration in retroperitoneal white AT, subscapular brown AT, periaortic AT as well as in its contiguous aorta free of perivascular AT. As expected, relative to lean rats (% body fat = 13.
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