Publications by authors named "Nicholas J Baltz"
Article Synopsis
- - The study uses a dual-age-specific mouse model to investigate how disrupted age-specific hematopoiesis might relate to leukemia, showing that loss of Pten during the transition from fetal to adult hematopoiesis can lead to juvenile leukemia and not contribute positively in the same age group.
- - It was found that juvenile mice display myeloid-biased hematopoiesis, linked to properties of fetal hematopoietic stem cells (HSCs), and that the development of juvenile myelomonocytic leukemia is influenced by the amounts of Pten and Nf1 genes present.
- - The research suggests that having just one copy of Pten is sufficient to keep the HSC function stable, despite activation of
Constitutively activated MAPK and AKT signaling pathways are often found in solid tumors and leukemias. PTEN is one of the tumor suppressors that are frequently found deficient in patients with late-stage cancers or leukemias. In this study we demonstrate that a MAPK inhibitor, PD98059, inhibits both AKT and ERK phosphorylation in a human myeloid leukemia cell line (TF-1), but not in PTEN-deficient leukemia cells (TF-1a).
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