Acceptability and Preferences of Simulation-Based Continuing Education Among Emergency Medical Service Providers.

Introduction: Simulation-based education (SBE) has been shown to be an effective and accepted teaching modality across multiple fields of medical education. Prehospital systems currently utilize simulation for initial training; however, few studies have determined the acceptability for simulation-based training for continued education among emergency medical service (EMS) providers.

Methods: We performed a retrospective mixed method review of data from prehospital provider evaluations of high-fidelity SBE training sessions.

Case Report of a Left-sided Superior Vena Cava Causing Unique Positioning of Central Line.

Introduction: Persistent left-sided superior vena cava is a rare congenital venous malformation. While often clinically asymptomatic, these variations in normal anatomy may give rise to complications with central venous catheter placement.

Case Report: We present a case of a 71-year-old male who presented to the emergency department with sepsis of unknown etiology.

Structure of the Escherichia coli ArnA N-formyltransferase domain in complex with N(5) -formyltetrahydrofolate and UDP-Ara4N.

ArnA from Escherichia coli is a key enzyme involved in the formation of 4-amino-4-deoxy-l-arabinose. The addition of this sugar to the lipid A moiety of the lipopolysaccharide of pathogenic Gram-negative bacteria allows these organisms to evade the cationic antimicrobial peptides of the host immune system. Indeed, it is thought that such modifications may be responsible for the repeated infections of cystic fibrosis patients with Pseudomonas aeruginosa.

Molecular structure of an N-formyltransferase from Providencia alcalifaciens O30.

The existence of N-formylated sugars in the O-antigens of Gram-negative bacteria has been known since the middle 1980s, but only recently have the biosynthetic pathways for their production been reported. In these pathways, glucose-1-phosphate is first activated by attachment to a dTMP moiety. This step is followed by a dehydration reaction and an amination.