CuO/CuO Nanoparticle-Cotton Fiber Biocomposite Catalyst: Self-Improvement through Morphological Changes during Methyl Orange Degradation.

In this study, the application of a novel polymer-supported CuO/CuO nanoparticle catalyst for the efficient degradation of an organic dye, in which the nanoparticle catalyst is incorporated within a natural plant fiber matrix, is presented. The use of plant fibers provides a renewable and environmentally friendly support material, and enhances the catalytic efficiency over consecutive degradation cycles. This innovative design promotes the efficient adsorption and degradation of dye.

Inhibiting mtDNA transcript translation alters Alzheimer's disease-associated biology.

Introduction: Alzheimer's disease (AD) features changes in mitochondrial structure and function. Investigators debate where to position mitochondrial pathology within the chronology and context of other AD features.

Methods: To address whether mitochondrial dysfunction alters AD-implicated genes and proteins, we treated SH-SY5Y cells and induced pluripotent stem cell (iPSC)-derived neurons with chloramphenicol, an antibiotic that inhibits mtDNA-generated transcript translation.

Repurposing Cotton Gin Trash for Cellulose Nanofibril-Silver Hybrid and Ultralight Silver-Infused Aerogel.

Cellulose nanofibril-silver (CNF-Ag) hybrid and ultralight silver-infused aerogel were produced using cotton gin trash (CGT), an abundant agro-waste material. This repurposing of CGT was achieved by exploiting its potential for CNF extraction and the in situ synthesis of silver nanoparticles (Ag NPs). CNFs were extracted from CGT through a mechanical shearing process.

On the Nature of Guest Complexation in Water: Triggered Wetting-Water-Mediated Binding.

The complexity of macromolecular surfaces means that there are still many open questions regarding how specific areas are solvated and how this might affect the complexation of guests. Contributing to the identification and classification of the different possible mechanisms of complexation events in aqueous solution, and as part of the recent SAMPL8 exercise, we report here on the synthesis and conformational properties of TEEtOA , a cavitand with conformationally flexible ethyl groups at its portal. Using a combination of ITC and NMR spectroscopy, we report the binding affinities of a series of carboxylates to and compare it to a related cavitand TEMOA .

Anti-epileptic drug topiramate upregulates TGFβ1 and SOX9 expression in primary embryonic palatal mesenchyme cells: Implications for teratogenicity.

Topiramate is an anti-epileptic drug that is commonly prescribed not just to prevent seizures but also migraine headaches, with over 8 million prescriptions dispensed annually. Topiramate use during pregnancy has been linked to significantly increased risk of babies born with orofacial clefts (OFCs). However, the exact molecular mechanism of topiramate teratogenicity is unknown.

Thermal properties and surface chemistry of cotton varieties mineralized with calcium carbonate polymorphs by cyclic dipping.

In this study, hydroentangled cotton nonwovens were identified as effective hosts for mineralization of calcium carbonate (CaCO) polymorphs to modify and improve their properties. All cotton varieties studied, including raw white cotton, scoured white cotton, and raw brown cotton, readily crystallized CaCO a simple cyclic dipping process. A combination of analyses agreed that the surface chemistry of cotton fibers influenced the formation of different CaCO polymorphs.

Proximal charge effects on guest binding to a non-polar pocket.

Science still does not have the ability to accurately predict the affinity that ligands have for proteins. In an attempt to address this, the Statistical Assessment of Modeling of Proteins and Ligands (SAMPL) series of blind predictive challenges is a community-wide exercise aimed at advancing computational techniques as standard predictive tools in rational drug design. In each cycle, a range of biologically relevant systems of different levels of complexity are selected to test the latest modeling methods.