Publications by authors named "Nicholas Dinardi"
Article Synopsis
- Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) have a higher chance of getting type of colon cancer called colorectal neoplasia (CRN) in the upper part of their colon.
- The study looked at how long and how badly they were inflamed to see if it linked to getting CRN.
- It found that more inflammation in the upper colon meant a greater risk of developing CRN, suggesting that checking and treating inflammation regularly could help prevent cancer.
Primary sclerosing cholangitis (PSC) is an immune-mediated disease of the bile ducts that co-occurs with inflammatory bowel disease (IBD) in almost 90% of cases. Colorectal cancer is a major complication of patients with PSC and IBD, and these patients are at a much greater risk compared to patients with IBD without concomitant PSC. Combining flow cytometry, bulk and single-cell transcriptomics, and T and B cell receptor repertoire analysis of right colon tissue from 65 patients with PSC, 108 patients with IBD and 48 healthy individuals we identified a unique adaptive inflammatory transcriptional signature associated with greater risk and shorter time to dysplasia in patients with PSC.
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