Network Pharmacology and Molecular Docking Analysis of Fruit Metabolites Suggest Anxiety Modulation through Glutamatergic Pathways.

The fruit of , also known as the noni tree, has been extensively used in Polynesian culture as an alternative medicine to various diseases. Recent studies have pointed out its anxiolytic activity in vitro and in mouse models. Despite the effectiveness of developed anxiolytic drugs in the market, the potential side effects of these medications have led people to resort to traditional medicine such as However, evidence regarding its anti-anxiety characteristics is still lacking to this day.