A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II.

Glycosaminoglycan (GAG) sequences that selectively target heparin cofactor II (HCII), a key serpin present in human plasma, remain unknown. Using a computational strategy on a library of 46 656 heparan sulfate hexasaccharides we identified a rare sequence consisting of consecutive glucuronic acid 2-O-sulfate residues as selectively targeting HCII. This and four other unique hexasaccharides were chemically synthesized.

A new route to metallacycloalkanes.

Reaction of the bis-alkenyl complex cis-[Pt(PPh3)2(CH2CH2CH=CH2)2] with Grubbs 1st generation catalyst gives, in high yield, the metallacycloalkene cis-[Pt(PPh3)2(CH2CH2CH=CHCH2CH2)], which can be hydrogenated to the metallacycloalkane cis-[Pt(PPh3)2(CH2)6].