Publications by authors named "Nicholas D Maxwell"
Article Synopsis
- * The research tested how leptin activates its receptors in the brain, specifically focusing on its impact on serotonergic neurons in the dorsal raphe nucleus (DRN) that communicate with the arcuate (ARC) region.
- * Results showed that leptin decreases food intake in rats by acting through these serotonergic neurons, highlighting a new pathway that connects leptin and serotonin in regulating eating behavior, which could lead to better treatments for eating disorders.
Article Synopsis
- Rac1 is a key intracellular signal transducer that influences actin remodeling and is linked to working memory and learning.
- Rac1 inhibition at presynaptic terminals disrupts spatial working memory, while inhibition at postsynaptic sites affects longer-term cognitive processes.
- The study identifies specific proteins involved in presynaptic Rac1 signaling that may regulate synaptic vesicle behavior and morphology, shedding light on its role in cognitive functions.
