Microaneurysm Detection Using Principal Component Analysis and Machine Learning Methods.

Diabetic retinopathy (DR) is an eye abnormality caused by long-term diabetes and it is the most common cause of blindness before the age of 50. Microaneurysms (MAs), resulting from leakage from retinal blood vessels, are early indicators of DR. In this paper, we analyzed MA detectability using small 25 by 25 pixel patches extracted from fundus images in the DIAbetic RETinopathy DataBase - Calibration Level 1 (DIARETDB1).

Radiogenomics of lower-grade glioma: algorithmically-assessed tumor shape is associated with tumor genomic subtypes and patient outcomes in a multi-institutional study with The Cancer Genome Atlas data.

Recent studies identified distinct genomic subtypes of lower-grade gliomas that could potentially be used to guide patient treatment. This study aims to determine whether there is an association between genomics of lower-grade glioma tumors and patient outcomes using algorithmic measurements of tumor shape in magnetic resonance imaging (MRI). We analyzed preoperative imaging and genomic subtype data from 110 patients with lower-grade gliomas (WHO grade II and III) from The Cancer Genome Atlas.

Algorithmic three-dimensional analysis of tumor shape in MRI improves prognosis of survival in glioblastoma: a multi-institutional study.

In this retrospective, IRB-exempt study, we analyzed data from 68 patients diagnosed with glioblastoma (GBM) in two institutions and investigated the relationship between tumor shape, quantified using algorithmic analysis of magnetic resonance images, and survival. Each patient's Fluid Attenuated Inversion Recovery (FLAIR) abnormality and enhancing tumor were manually delineated, and tumor shape was analyzed by automatic computer algorithms. Five features were automatically extracted from the images to quantify the extent of irregularity in tumor shape in two and three dimensions.

The impact of time on seizure prediction performance in the FSPEEG database.

We demonstrate evidence that high discriminability between preictal and interictal intracranial electroencephalogram (iEEG) recordings [1,2] of the Freiburg database (FSPEEG) may be due to the amount of time that occurred between recordings, as opposed to the underlying seizure state, i.e., preictal or interictal.

An analysis of resting-state functional transcranial Doppler recordings from middle cerebral arteries.

Functional transcrannial Doppler (fTCD) is used for monitoring the hemodynamics characteristics of major cerebral arteries. Its resting-state characteristics are known only when considering the maximal velocity corresponding to the highest Doppler shift (so called the envelope signals). Significantly more information about the resting-state fTCD can be gained when considering the raw cerebral blood flow velocity (CBFV) recordings.