Alzheimer's disease (AD) in multiple sclerosis (MS): A systematic review of published cases, mechanistic links between AD and MS, and possible clinical evaluation of AD in MS.

: Alzheimer's disease (AD) and multiple sclerosis (MS) are two neurological disorders that can pose enormous burden to a person's quality of life. Due to new therapeutic advancements that significantly extend the lifespan, there may be an increased prevalence of AD in elderly MS patients. Building on a previous review on MS-AD coexistence, this review not only aimed to broaden the pool of literature searched, but also investigated possible mechanistic links between clinical markers for MS and AD.