Publications by authors named "Nicholas Ciancio"
Article Synopsis
- Postoperative cognitive dysfunction (POCD) is being increasingly acknowledged as a significant issue after surgery, with a consensus suggesting it be categorized by recovery timelines: within 30 days post-surgery vs. between 30 days to 12 months.
- Research indicates that the type of anesthesia used—either inhalational or total intravenous anesthesia (TIVA)—may impact the likelihood of experiencing POCD, with TIVA showing a lower incidence in the first 30 days after surgery.
- A comprehensive review yielded differing amounts of studies and patients for POCD analysis, and while TIVA was beneficial in the short term, more rigorous and uniform studies are needed to understand the long-term effects of anesthesia on cognitive recovery.
Unlabelled: Recent interest in the antidepressant and anti-stress effects of subanesthetic doses of ketamine, an NMDA receptor antagonist, has identified mechanisms whereby ketamine reverses the effect of stress, but little is known regarding the prophylactic effect ketamine might have on future stressors. Here we investigate the prophylactic effect of ketamine against neurochemical and behavioral changes that follow inescapable, uncontrollable tail shocks (ISs) in Sprague Dawley rats. IS induces increased anxiety, which is dependent on activation of serotonergic (5-HT) dorsal raphe nucleus (DRN) neurons that project to the basolateral amygdala (BLA).
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