Publications by authors named "Nicholas C Castro"
Article Synopsis
- Serology testing is vital for assessing the effectiveness of COVID-19 vaccines and detecting past infections by measuring antibodies against SARS-CoV-2.
- This study validated four laboratory-developed serology tests for antibodies (IgG and IgM) against Spike and Nucleocapsid proteins, ensuring they met strict Clinical and Laboratory Standards Institute (CLSI) guidelines for reliability.
- Results showed good linearity and precision across the tests, demonstrating their validity for identifying levels of antibodies, which is crucial for ongoing COVID-19 research and management.
Article Synopsis
- SARS-CoV-2 serology is important for assessing COVID-19 vaccine effectiveness and immune response, but factors like tube type and anticoagulant can affect results.
- The study found no significant differences in antibody levels based on tube type; however, tubes with anticoagulants sodium citrate and ACD showed lower antibody concentrations, which were mostly adjusted after considering dilution factors.
- There were noticeable differences in IgG avidity between plasma and serum, suggesting that plasma treated with anticoagulant cannot be considered interchangeable with serum for certain assays, warranting further exploration.
