Skin wound closure delay in metabolic syndrome correlates with SCF deficiency in keratinocytes.

Poor wound closure due to diabetes, aging, stress, obesity, alcoholism, and chronic disease affects millions of people worldwide. Reasons wounds will not close are still unclear, and current therapies are limited. Although stem cell factor (SCF), a cytokine, is known to be important for wound repair, the cellular and molecular mechanisms of SCF in wound closure remain poorly understood.

Boundary Disputes: In Inflamed Skin, Mast Cells Expand and Disorganize Stable Clonal Territories.

Skin mast cells (MCs) are distinct from other MCs, and for years, we have tried to understand their origin and peculiarities. A recent study demonstrated that during development, MCs enter the skin from the yolk sac and embryonic liver and are later mixed with cells originating from the bone marrow. A report from Weitzmann et al.