Publications by authors named "Nicholas B Buchner"
Article Synopsis
- Prostate tumours show diverse responses to treatment, and current prognostic factors only account for some of this variation, prompting further investigation into their genetic profiles.* -
- Analysis of 200 whole-genome and 277 whole-exome sequences revealed that localized, non-indolent tumours lack key mutations found in metastatic cases, instead featuring non-coding changes and large-scale rearrangements.* -
- Many genetic abnormalities were linked to disease recurrence, and a new signature of these abnormalities was found to be more effective than established biomarkers, suggesting that targeted treatments could enhance cure rates for aggressive localized prostate cancer.*
Background: Quantitative real-time PCR (qPCR) is the "gold-standard" technique for measuring mRNA abundances. To correctly compare samples and generate biologically valid results, qPCR data usually require comprehensive normalization to account for sample content variation between reactions. The most common normalization approaches use one or more endogenous controls (reference or house-keeping genes) to adjust the measured levels of experimental genes appropriately.
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