Publications by authors named "Nicholas Averell"

Aim: Vaccines have been shown to have the highest efficacy in preventing infectious diseases through their ability to induce immunological memory against pathogens. An adverse reaction to a vaccine is an unexpected medical occurrence following immunization. Complex regional pain syndrome (CRPS) is a disease that has undergone much controversy regarding its onset post-vaccination.

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Regenerative medicine, specifically bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP), has become a novel adjunct that orthopedic surgeons have started to use with surgical rotator cuff repairs (RCR). Thus, we are conducting this systematic review to determine if either RCRs with BMAC alone or with BMAC and PRP result in superior functional outcomes. We conducted a comprehensive search using five databases including PubMed, Web of Science, Embase, Scopus, and Cochrane.

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Article Synopsis
  • * 1408 articles were initially reviewed across five medical databases, with 20 studies meeting the criteria for inclusion in the analysis.
  • * The study found no significant difference in pain outcomes between high and low platelet concentration groups, concluding that platelet concentration does not influence overall pain relief from PRP injections.
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To investigate the potential benefit of topical capsaicin formulations. A narrative systematic review was employed. About 8% capsaicin patches were found to significantly reduce symptoms of diabetic peripheral neuropathy.

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We aimed to expound upon previous research examining the effect of platelet rich plasma in the treatment of sacroiliac joint (SIJ) dysfunction and pain. A systematic review was employed in conjunction with a pooled analysis of the efficacy of platelet-rich plasma (PRP) in SIJ dysfunction and pain.  A total of 259 articles were retrieved following database systematic review.

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