Cellular injury leading to oxidative stress in acute poisoning with potassium permanganate/oxalic acid, paraquat, and glyphosate surfactant herbicide.

Previous studies on human acute kidney injury (AKI) following poisoning with potassium permanganate/oxalic acid (KMnO/HCO), paraquat, and glyphosate surfactant herbicide (GPSH) have shown rapid and large increases in serum creatinine (sCr) that cannot be entirely explained by direct nephrotoxicity. One plausible mechanism for a rapid increase in sCr is oxidative stress. Thus, we aimed to explore biomarkers of oxidative stress, cellular injury, and their relationship with sCr, after acute KMnO/HCO, paraquat, and GPSH poisonings.

Antidepressant therapy in cancer patients: initiation and factors associated with treatment.

Purpose: We assessed the impact of a cancer diagnosis and its timing on antidepressant initiation. We also examined patterns of, and factors associated with, new antidepressant treatment in cancer patients.

Methods: We followed 61 067 antidepressant-naive Australian Government Department of Veterans' Affairs clients.

A simple quantitative bedside test to determine methemoglobin.

Study Objective: Methemoglobinemia after pesticide poisoning is associated with a mortality of 12% in Sri Lanka. Treatment is complicated by the lack of laboratory facilities. We aimed to develop and validate a low-cost bedside test for quantitative estimation of clinically significant methemoglobin to be used in settings of limited resources.