Publications by authors named "Nicholas Aldridge"
Article Synopsis
- Respiratory syncytial virus (RSV) poses serious health risks for young children and elderly individuals, with current vaccines mainly available for adults over 60 and temporary protection for infants through maternal antibodies.
- Researchers have developed a new type of vaccine that uses an anti-idiotypic monoclonal antibody (ai-mAb) specifically designed to target B cell receptors capable of producing RSV-neutralizing antibodies.
- This novel approach effectively engages the right B cells without triggering unwanted immune responses, showcasing potential for a more effective infant vaccine against RSV.
Purpose: The National Congenital Anomaly and Rare Disease Registration Service (NCARDRS), part of National Disease Registration Service in National Health Service England, quality assures, curates and analyses individual data on the pregnancies, fetuses, babies, children and adults with congenital anomalies and rare diseases across England. The congenital anomaly (CA) register provides a resource for patients and their families, clinicians, researchers and public health professionals in furthering the understanding of CAs.
Participants: NCARDRS registers CAs occurring in babies born alive and stillborn, fetal losses and terminations in England.
Objective: To measure condition-specific detection rates for 14 physical conditions screened for by the NHS fetal anomaly screening programme (FASP) fetal anomaly (FA) ultrasound scan.
Design: Retrospective audit of 12 694 diagnoses across a 3-year national cohort.
Setting: All English NHS and crown-dependency hospital trusts providing maternity services.
Pediatric respiratory distress: California out-of-hospital protocols and evidence-based recommendations.
J Am Coll Emerg Physicians Open
October 2020
Objectives: Prehospital protocols vary across local emergency medical service (EMS) agencies in California. We sought to develop evidence-based recommendations for the out-of-hospital evaluation and treatment of pediatric respiratory distress, and we evaluated the protocols for pediatric respiratory distress used by the 33 California local EMS agencies.
Methods: Evidence-based recommendations were developed through an extensive literature review of the current evidence regarding out-of-hospital treatment of pediatric patients with respiratory distress.
Objective: To evaluate, in a well-controlled study, the effect of surgically induced partial bladder outlet obstruction (PBOO) on male erectile function in a rat model.
Materials And Methods: PBOO was created in 17 adult male Sprague-Dawley rats by partial ligation of the proximal urethra. Sham-operated and PBOO rats were evaluated for urodynamic and erectile function at 4-8 weeks after surgery.